Institute of Molecular Biology (IMB) NAS RA
Director - Dr. A. Boyajyan
The scientific profile of (IMB): The regulation of cell activity on metabolic and genetic levels under normal and pathological conditions. IMB consists from 10 laboratories with following main fields of activity:
| Laboratory | Head |
Research Fields |
|---|---|---|
| Department of molecular bases of lipidology |
Free radical peroxidation processes in different biological systems and effectiveness of combined antiradical therapy. Biochemistry of new metal-containing proteins and enzymes in the brain and other organs, cardioactive hormones influence cardioactive hormones on the heart diseases. The regulatory systems participating in equilibration of pro- and antioxydative mechanisms of normally functioning cell corpuscles; the mechanisms providing the stability of endogenous systems of antiradical protection of cells. Molecular pathomechanisms of lipid metabolism disorders. Free radical protecting systems, natural and artificial antioxidants. Involvement of membrane structures in radioprotection mechanisms. Molecular pathomechanisms of poisonings of different nature. Chromatin structural transitions and the regulation of transcription; chromatin- phospholipid interrelations. Modified in the IMB forms of dsRNA with the antibacterial and antivirial activity. |
|
Laboratory of molecular structure and macromolecular complexes |
Lipid-protein interactions, macromolecular complex formation processes. Cell differentiation and diseases. Immune response regulation and autoimmune processes. Molecular pathomechanisms of schizophrenia disorder. |
|
Department of cell physico-chemial biology |
DNA hyperreplication phenomenon. DNA replication and reparation. |
|
Laboratory of molecular genetics |
Role of R-plasmid in development of infectious diseases. |
|
Laboratory of regulation of cell activity |
Isoenzymes and adaptation, transmembrane signaling. Molecular pathomechanisms of leukemia disorder. |
|
Laboratory of organo-specific proteines |
Strucrural, functional and metabolic characteristics of neurospecific enolase. |
|
Laboratory of molecular enzimology |
The enzymes activity regulatory mechanisms on the quaternary structure. |
|
Laboratory of physico-chemistry of enzymes |
Metabolic enzymes structural organization on molecular and supramolecular levels. Metabolic enzymes structural organization on molecular and supramolecular levels. Structural, functional and metabolic properties of glutamatdehydrogenase, ADP- polymerase. |
|
Laboratory of intracellular interrelations |
Anticancer drugs binding on DNA. DNA repair in eukaryotes. The effects of exogenic nucleic acids upon penetration in pro- and eukaryotic cells. Apoptosis and its regulation on gene level. |
|
Department of electron microscopy |
Morpho-structural characterization of cells and subcellular corpuscles under different extremal and pathological states of the organism. |